| Issue Date | Title | Author(s) |
| Nov-2020 | Crystal structure of the GDP-bound GTPase domain of Rab5a from Leishmania donovani | Biswal, Bichitra K; Pohl, Ehmke; Arora, Ashish; Zohib, Muhammad; Maheshwari, Diva; Pal, Ravi Kant; Freitag-Pohl, Stefanie |
| Aug-2021 | Designing novel anti-TB inhibitors by targeting imidazole glycerol phosphate dehydratase (HisB) from Mycobacterium tuberculosis | Kumar, Deepak; Biswal, Bichitra K |
| Apr-2021 | Dissecting the Mechanistic Properties of HisI (Rv1606) and the Dynamics of Histidine Biosynthesis Enzymes in in-vivo Infection of Mycobacterium tuberculosis | Ashraf, Anam; Biswal, Bichitra K |
| Jul-2021 | Fabrication and characterization of functionalized polymeric scaffold for bone tissue engineering | Verma, Juhi; Panda, Amulya K; Biswal, Bichitra K |
| Nov-2011 | HisB from Mycobacterium tuberculosis: cloning, overexpression in Mycobacterium smegmatis, purification, crystallization and preliminary X-ray crystallographic analysis | Biswal, Bichitra K; Ahangar, Mohammad Syed; Khandokar, Yogesh; Nasir, Nazia; Vyas, Rajan |
| Aug-2021 | Improved immunogenicity of recombinant protein using biodegradable polymer particles | Ahuja, Rahul; Biswal, Bichitra K; Panda, Amulya K |
| Aug-2021 | Improvement To The Cow Genome Annotation Through Integrated Transcriptomic And Proteomic Analysis | Md. Qudratullah; Biswal, Bichitra K; Panda, Amu |
| Sep-2012 | Mammalian zona pellucida glycoproteins: structure and function during fertilization | Gupta, Satish Kumar; Bhandari, Beena; Shrestha, Abhinav; Biswal, Bichitra K; Palaniappan, Chetna; Malhotra, Sudha Saryu; Gupta, Neha |
| Jul-2021 | Molecular And Therapeutic Investigation Into Taurine Regulation Of Bone Mass | Singh, Parminder; Biswal, Bichitra K; Panda, Amulya K |
| Jan-2012 | Molecular cloning, overexpression, purification, crystallization and preliminary X-ray diffraction studies of histidinol phosphate aminotransferase (HisC2) from Mycobacterium tuberculosis | Biswal, Bichitra K; Nasir, Nazia; Vyas, Rajan; Chugh, Chetna; Ahangar, Mohammad Syed |
| Mar-2021 | De novo histidine biosynthesis protects Mycobacterium tuberculosis from host IFN-γ mediated histidine starvation | Biswal, Bichitra K; Dwivedy, Abhisek; Ashraf, Anam; Jha, Bhavya; Kumar, Deepak; Agarwal, Nisheeth |
| Jul-2014 | Overexpression, purification, crystallization and structure determination of AspB, a putative aspartate aminotransferase from Mycobacterium tuberculosis | Biswal, Bichitra K; Saroj, Deepak Chandra; Singh, Khundrakpam Herojit; Anant, Avishek |
| Jul-2020 | Prediction of Small Molecule Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus-2 RNA-dependent RNA Polymerase | Biswal, Bichitra K; Jeyakanthan, Jeyaraman; Kar, Deepsikha; Tiwari, Satish; Ahmad, Mohammed; Dwivedy, Abhisek; Mariadasse, Richard |
| Apr-2013 | Sample preparation, crystallization and structure solution of HisC from Mycobacterium tuberculosis | Biswal, Bichitra K; Nasir, Nazia; Vyas, Rajan |
| Jul-2019 | Structural insights into the substrate specificity of SP_0149, the substrate-binding protein of a methionine ABC transporter from Streptococcus pneumoniae | Biswal, Bichitra K; Jha, Bhavya; Vyas, Rajan; Bhushan, Jaya; Sehgal, Devinder |
| Jul-2019 | Structural insights into the substrate specificity of SP_0149, the substrate-binding protein of a methionine ABC transporter from Streptococcus pneumoniae | Sehgal, Devinder; Biswal, Bichitra K; Jha, Bhavya; Vyas, Rajan; Bhushan, Jaya |
| Dec-2013 | Structures of native, substrate-bound and inhibited forms of Mycobacterium tuberculosis imidazoleglycerol-phosphate dehydratase | Biswal, Bichitra K; Ahangar, Mohammad Syed; Vyas, Rajan; Nasir, Nazia |
| Jul-2022 | The unintended crystallization of proteins which generally originate from the expression host instead of the target recombinant proteins is periodically reported. Despite the massive technological advances in the field, assigning a structural model to the corresponding diffraction data is not a trivial task. Here, the structure of acyl-carrier protein synthase (AcpS) from Mycobacterium smegmatis (msAcpS), which crystallized inadvertently in an experimental setup to grow crystals of a Mycobacterium tuberculosis protein using M. smegmatis as an expression system, is reported. After numerous unsuccessful attempts to solve the structure of the target protein by the molecular-replacement method no convincing solutions were obtained, indicating that the diffraction data may correspond to a crystal of an artifactual protein, which was finally identified by the Sequence-Independent Molecular replacement Based on Available Databases (SIMBAD) server. The msAcpS structure was solved at 2.27 Å resolution and structural analysis showed an overall conserved fold. msAcpS formed a trimeric structure similar to those of other reported structures of AcpS from various organisms; however, the residues involved in trimer formation are not strictly conserved. An unrelated metal ion (Ni2+), which was possibly incorporated during protein purification, was observed in the proximity of His49 and His116. Structural and sequence differences were observed in the loop connecting the α3 and α4 helices that is responsible for the open and closed conformations of the enzyme. Moreover, the structural analysis of msAcpS augments the current understanding of this enzyme, which plays a crucial role in the functional activation of acyl-carrier proteins in the fatty-acid biosynthesis pathway. | Biswal, Bichitra K; Bhatia, Indu; Yadav, Savita |
